Addition of an extra MetS criterion point for AAs with hypertension eliminated the racial differences in PWV and CAIx but not RHI.Īlthough MetS is associated with microvascular dysfunction and increased arterial stiffness in both racial groups, AAs without MetS have greater vascular dysfunction compared with whites. However, in subjects without MetS, AAs had lower RHI (P <. MetS was present in 24.0% of subjects and was associated with increased PWV (P <. Using applanation tonometry (Sphygmocor), central augmentation index (CAIx) and pulse wave velocity (PWV) were measured as indices of wave reflections and arterial stiffness, respectively. Radical surgical resection of a localized tumor is. Adrenocortical carcinoma (ACC) is among the deadliest endocrine malignancies. Institut de Pharmacologie Moléculaire et Cellulaire Centre National de la Recherche Scientifique, 660 Route des Lucioles, Sophia Antipolis, 06560 Valbonne, France. Using digital pulse amplitude tonometry, we estimated the reactive hyperemia index (RHI), a measure of microvascular endothelial function. Mitotane Revisited: A New Target for an Old Drug. We measured components of MetS in a community-based cohort of 951 AAs and white subjects (aged 48.8 ± 11 y, 47% AA, 55% female). The objective of the study was to evaluate the relationship between MetS and vascular function in a biracial cohort with the hypothesis that the diagnosis of MetS underestimates subclinical vascular disease in AAs. Both mineralocorticoid (MRs) and glucocorticoid receptors (GRs) can mediate these effects.
African Americans (AAs) have high rates of cardiovascular disease and subclinical vascular disease including arterial stiffness and microvascular dysfunction but have relatively low rates of MetS. DOI: 10.1210/en.2015-1390 Abstract Adrenal glucocorticoid hormones are potent modulators of brain function in the context of acute and chronic stress. The diagnosis of metabolic syndrome (MetS) identifies individuals at risk for developing diabetes and cardiovascular disease.
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